Hamilton is Ypsilanti's southbound through street, carrying traffic from the EMU campus / Huron River Drive area south past Cross, Washtenaw, and downtown Ypsilanti to I-94, where it merges with northbound Huron Street (Ypsilanti).

From the north:

• St. John the Baptist Catholic Church

• Madonna Park
• The Ugly Mug

• Here M-17 leaves Washtenaw to continue south on Hamilton.

• EMU College of Business
• Abe's Coney Island

• Here Hamilton additionally becomes US-12 (Business Loop)
• Key Bank Building and Keybank Farmers Market
• Towne Centre Place senior housing

• Post Office

• 596 S. - Parkview Apartments

Ends.